Nanovaccine Delivery Systems in Vaccine Formulations

The important biological molecules such as polysaccharides, proteins, allergens and Pathogen Associated Molecular Patterns (PAMPs) are of nanometer in size. Hence, the size, charge, hydrophobic properties will influence their effects on the immune system by way of specific and varied response. Vaccines play a pivotal role in disease containment and prevention. One of the bottle necks is the vaccine administration system. Earlier vehicles and adjuvant systems pose unwanted reactions due to the nature of delivery system used in the vaccine. Delivery systems are those materials used for the administration of vaccines s in a controlled manner aimed to achieve a therapeutic effect. These systems provide: cell or tissue targeted delivery of the antigen, improved antigen presentation, solubility, sustained release and protection of the prophylactic agent from degradation.